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Testing Method:
Blood draw
Insulin Resistance
Insulin resistance occurs when the body’s cells become less responsive to insulin, the hormone responsible for moving glucose (sugar) from the bloodstream into the cells for energy. As a result, the body needs to produce higher amounts of insulin to keep blood sugar levels balanced.
Over time, this increased demand on the pancreas can lead to rising insulin and blood glucose levels. If left unmanaged, insulin resistance may progress to pre-diabetes or type 2 diabetes and may increase the risk of long term health complications.
Insulin resistance is commonly assessed using the HOMA score (Homeostasis Model Assessment), which is calculated from fasting glucose and fasting insulin levels. Higher HOMA scores generally indicate greater levels of insulin resistance.
Insulin resistance is also a key feature of Metabolic Syndrome, a group of risk factors that may increase the likelihood of cardiovascular disease and diabetes.
These risk factors can include:
- Increased abdominal weight gain
- Elevated LDL cholesterol and triglycerides
- Low HDL (“good”) cholesterol
- High blood pressure
- Elevated blood glucose levels
Several lifestyle and genetic factors may contribute to insulin resistance, including:
- Family history of diabetes
- Diets high in refined carbohydrates and sugar
- Excess alcohol intake
- Lack of regular exercise
- Chronic stress
- Nutritional deficiencies such as magnesium, chromium and other key nutrients
Common conditions associated with insulin resistance include:
- Obesity
- Pre-diabetes
- Type 2 diabetes
- Cardiovascular disease
- High blood pressure
- High cholesterol
- Elevated triglycerides
Early identification of insulin resistance can allow for targeted dietary, lifestyle and nutritional interventions aimed at improving blood sugar regulation, metabolic health and long term wellbeing.

